Process scale purification of antibodies. Uwe Gottschalk

Process scale purification of antibodies



Download Process scale purification of antibodies



Process scale purification of antibodies Uwe Gottschalk ebook pdf
Publisher: John Wiley & Sons
Language: English
Page: 445
ISBN: 0470209623, 9780470209622

Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification.

From the Back Cover

The cutting edge in antibody purification written by industry experts

Biopharmaceutical companies are under extreme pressure to develop robust and economical large-scale processes while consistently meeting regulatory standards for safety and purity. Traditional column chromatography dominates today's purification trains, and many of the productivity gains rely on upscaling such devices. This comes with a cost penalty, however, and further increases in upstream productivity make it a challenge to keep downstream processing manageable. Advances in purification technology are urgently needed to meet the requirements of the marketplace without sacrificing product quality.

Process Scale Purification of Antibodies offers scientists, researchers, and engineers an essential resource that focuses on current best practice in the manufacturing of antibody drugs, addresses problems in antibody purification, and offers suggestions to overcome current challenges and limitations. Written by experts in the field, the book examines old and new separation methods and includes an analysis of innovative trends that can help meet the economic pressures and escalating demand for antibody drugs.

Process Scale Purification of Antibodies:

Provides an overview of state-of-the-art methods in the downstream processing of therapeutic antibodies

Compiles information for the development of generic platform purification processes

Analyzes innovative technology trends such as weak partitioning chromatography, charged membranes, and new precipitation methods, as well as orthogonal and integrated strategies to improve throughput

Provides resources for solving technical challenges in antibody manufacturing

Discusses the economic drivers and benchmark values in antibody purification



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